At about 7.45am, emergency services were called to the intersection of Boundary Lane and the Barton Highway, Wallaroo, after reports a Toyota Landcruiser and Dodge Journey had collided.

Police were told one of the vehicles then crashed into a Mazda 6 station wagon as a result of the collision.

Two female passengers, aged 36 and 34 years old, of the Dodge Journey died at the scene.

The driver of the Dodge Journey, a 39-year-old man, two girls (aged 16 and 22-months) and a boy (aged 8) were taken to Canberra Hospital with non life-threatening injuries.

A 12-year-old girl was taken to Canberra Hospital before being flown to Prince of Wales Hospital, Randwick, in a serious condition.

A 65-year-old man, the driver and sole occupant of the Toyota Landcruiser, suffered non life-threatening injuries.

He was also taken to Canberra Hospital.

The driver of the Mazda 6 station wagon, a 58-year-old female, and two male passengers were uninjured.

All three drivers were taken to hospital for mandatory testing.

Officers from The Hume Police District, with assistance from the Crash Investigation Unit, established a crime scene and began an investigation into the incident.

As inquires continue, anyone with information is urged to come forward.

Police are urging anyone with information in relation to this incident to call Crime Stoppers on 1800 333 000 or use the Crime Stoppers online reporting page: nsw.crimestoppers.com.au.

Information you provide will be treated in the strictest of confidence. We remind people they should not report crime information via our social media pages.