The major hubs - which also include Newcastle, Wagga Wagga, Coffs Harbour and Dubbo - and their linked satellite sites will open progressively through to April.

The vaccine will be dispatched from the hubs to a total of 99 regional satellite sites across the state.

Wollongong's satellite sites will be at Bombala, Braidwood, Cooma, Delegate, Goulburn, Milton, Shellharbour and in the Shoalhaven.

These vaccination hubs and satellite sites will initially focus on frontline healthcare and border workers, and will eventually be followed by a wider rollout of the vaccine to the general public through the GP network.

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Health Minister Brad Hazzard said rolling out vaccinations to frontline staff in the regions is the next step to ensuring they are protected against COVID-19.

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"Wollongong and Newcastle are particularly significant because we have frontline staff meeting overseas freighters arriving at ports and those staff obviously are at higher risk than others," Mr Hazzard said.

Chief Health Officer Dr Kerry Chant said the expansion is a major boost for the state's frontline healthcare workers, especially those in regional NSW.

"An important aspect of the continued rollout is ensuring everyone at risk of COVID-19 has access to vaccination as close to their homes as possible," Dr Chant said.

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