Northern Territory police confirmed the man died after being struck by a vehicle that left the track on Monday morning, 35km from the start/finish line.

The man in his 60s was a spectator at the event and died at the scene.

The area has been cordoned off and competitors have been diverted from the area, which has been declared a crime scene.

A male spectator in his 50s was also injured in the incident and will be taken to the Royal Adelaide Hospital on Tuesday, police say.

The female navigator of the vehicle, aged in her 50s, received minor injuries and was taken to Alice Springs Hospital.

NT Health says both are in a stable condition.

Motorsport Australia confirmed on its Facebook page arrangements will be made with police for vehicles stopped on the course at various locations on the Finke Track to be recovered by crews.

They also confirmed the car section of the race has been concluded by the clerk of the course.

Police are asking any witnesses or anyone that may have video footage of the incident to contact them.

According to the race website, the Tatts Finke Desert Race is an off-road multi-terrain two-day race for bikes, cars, buggies and quads through desert country from Alice Springs to Aputula (Finke).

Held annually on the Queen's Birthday long weekend in June, it's one of the biggest annual sporting events in the Northern Territory.

The race is one of the most difficult off-road remote courses in the world.

Australian Associated Press